Mechanism of Action
Phexxi®: a first-in-class, non-hormonal vaginal contraceptive gel with a unique MOA1
Watch this video to see how Phexxi works by maintaining an acidic vaginal pH and decreasing sperm motility.
Phexxi has an MOA specifically designed to prevent pregnancy
Phexxi is a non-hormonal birth control containing active ingredients lactic acid, citric acid, and potassium bitartrate.2 Phexxi is a first-in-class vaginal pH modulator (VPM)1; it is not a spermicide.
The introduction of seminal fluid changes vaginal pH. The active ingredients in Phexxi prevent pregnancy by maintaining an acidic vaginal pH, which creates an inhospitable environment for sperm.2-5
In vitro studies with Phexxi show immediate sperm motility reduction through the maintenance of an acidic vaginal pH and the creation of a viscous gel barrier.2-5
How Phexxi works
Vaginal pH modulation
Phexxi maintains an acidic vaginal pH, even in the presence of semen, which creates an inhospitable environment for sperm.2-5
The buffering capacity of Phexxi reduces the availability of calcium ions, which are needed to drive sperm tail movement.6
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Unique gel formulation
The bioadhesive properties of Phexxi keep the gel in place to maintain an acidic vaginal pH. The viscous properties of Phexxi make it difficult for sperm to travel toward the cervix.2-5
Images are for illustrative purposes only.