Phexxi® is proven to prevent pregnancy without the use of hormones
Results of AMPOWER—a Phase 3, multicenter, single-arm, open-label clinical triala (N=1384)
OVER 7 CYCLES1
OVER 7 CYCLES2
POST HOC ANALYSIS
PER ACT OF INTERCOURSE1,3
Based on 101 pregnancies (n=1182) over 24,289 acts of intercourse with typical use. Per-act-of-intercourse pregnancy risk of 0.415%
Post hoc analysis was not statistically tested in the clinical trial. Data are not in the USPI and should be interpreted with caution.
Phexxi is a non-hormonal, bioadhesive gel that works by maintaining an acidic vaginal pH and decreasing sperm motility. In clinical studies, Phexxi was proven effective and safe.
Watch this video to see instructions for the correct use of Phexxi. You can also share this video with your patients so they understand how to use Phexxi.
Phexxi offers a non-hormonal side effect profile4
Phexxi is non-systemic, and systemic exposure is not expected to lead to safety concerns.4
The majority of adverse reactions in clinical trials (≥10%) were mild, and few led to discontinuation:
- Vulvovaginal burning sensation (18.0%)
- Vulvovaginal pruritus (14.5%)
- Only 1.6% discontinued due to adverse reactions
- Two subjects discontinued due to male partner symptoms, and less than 10% of male partners reported local discomfort
Phexxi can meet the personal needs of women
Phexxi has not been studied in breastfeeding women; however, Phexxi works locally and may be an appropriate choice for breastfeeding women.
In clinical studies, couples were allowed to engage in oral sex, and no side effects directly related to oral sex were reported.
Phexxi may be used with latex, polyurethane, and polyisoprene condoms, as well as vaginal diaphragms. Avoid Phexxi use with vaginal rings.